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Traditional I/O Calibration

For biopharmaceutical manufacturing, accuracy and reliability are of the utmost importance. To verify the quality and safety of the final product, the equipment and instrumentation used in the process must be calibration and an important piece of instrumentation is traditional input/output (I/O). The team at GL Technologies is an ISO 17025 certified company that provides equipment calibration and certification services for biopharmaceutical company's throughout California. We keep our client's equipment both accurate while keeping our clients in compliance with industry regulations such as the FDA and cGMP.

To speak with the experts about your traditional I/O calibration needs, please fill out our online form or give us a call!


What is Traditional I/O in a Laboratory?

Traditional I/O stands for "input/output", which refers to the conventional methods of handling data and communication within a laboratory. In a lab, traditional I/O involves the manual exchange of information and physical materials between researchers, instruments, and devices. It can include activities such as manually recording experimental data, or the transfer of samples between different equipment, and using physical interfaces like buttons to control lab instruments. Traditional I/O methods rely on human interventions and physical interactions which can be both time-consuming and prone to human error. They have been used for decades in lab settings and continue to play a role in various research disciplines.

Importance in Biopharma Manufacturing

Process Consistency

Traditional I/O practices contain the fundamental aspects of raw material sourcing, production, and overall quality control which are important to maintain the integrity of biopharmaceutical products. From the selection of quality starting materials to monitoring of process parameters, traditional I/O serves as a cornerstone in gauranteeing the reliability of biopharma manufacturing processes. By sticking to established I/O protocols, manufacturer's can minimize the risk of batch-to-batch variability to achieve consistent product quality. The preservation and improvement of traditional I/O practices remains indispensable in process consistency.

Accurate Data Acquisition

Traditional I/O systems, including sensors and control devices also play an important role in monitoring various parameters like temperature, pressure, pH levels and flow rates. With real-time data and manufacturing variables, traditional I/O allows manufacturers to maintain the best conditions for product quality and meeting regulatory standards such as cGMP (Current Good Manufacturing Processes). The accurate data acquisition facilitates process improvement and early detection of any deviations that allows for quick corrective actions.


By maintaining records of inputs and outputs, biopharma companies can demonstrate traceability and the ability to identify and fix any deviations. These traditional I/O practices play a pivotal role in maintaining complance with strict regulations, verifying product safety and fostering public trust.

Best Practices for Traditional I/O Calibration

Establish Calibration Procedures

To start ,it's important to clearly define the scope and purpose of the calibration while identifying the specific inputs and outputs to be calibrated. This helps to determine the necessary equipment and standards required for the calibration process. Documenting step-by-step calibration procedures with detailed instructions is important to for consistency and repeatability. This includes specifying measureent points, calibration methods, and acceptable criteria. It's also important to establish a regular calibration schedule to verify that all instruments are calibrated at appropriate intervals to minimize the risk of drift. By following the best practices, biopharma organizations can achieve reliable I/O calibration which leads to improved measurements and accuracy.

Use Traceable Standards

Traceability verifies that the calibration process is reliable and accurate, giving confidence in the measurement results. By using traceable standards technicians can establish a clear chain of measurement that is linked to industry reference standards. This shows that the calibration equipment used is calibrated against higher-level standards which increases the reliability and comparability of measurements.

Regular Calibration Schedule

Implementing a calibration schedules is a fundamental best practice for traditional input/output calibration to provide accurate and reliable measurements continuously. Sticking to a consistent calibration timeline works to maintain the integrity of the measurement system and minimizes the risk of errors. It is recommend to establish a calibration schedule based on the manufacturer's guidelines and industry standards. Regularly scheduled calibration works to dtect and correct any deviation in the system, guaranteeing traceable results.

Document Calibration Records

By maintaining comprehensive records, organizations can prove the traceability and integrity of their calibration process. These records should include all details such as the instrument's identification, calibrate date, technician or company name, standards used and measurement uncertainties. Any adjustments or repairs made during calibration should be documented, as this recordkeeping serves multiple purposes including evidence of compliance with quality standards, facilitating trend analysis, and supporting troubleshooting efforts.

Why GL-Tec?

The GL Technologies team has the experience and equipment to calibrate all types of display equipment accurately. We understand the importance of accurate measurements in your specific industry, and we're committed to providing you with reliable, traceable calibration services.

Our calibration services are ISO 17025 accredited, and we follow strict quality control procedures. Your equipment is calibrated to the highest standards. We also provide fast turnaround times, so you can get back to work with minimal downtime.

To speak with the experts about your traditional I/O calibration needs, please fill out our online form or give us a call!



To request a quote from GL-Tec, please fill out our online form and we will get back to you promptly.


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