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Centrifuge Calibration

Centrifgures play an important role in the biopharmaceutical industry, "centrifugation" provides for the separation and and purification of various biomolecules like proteins, nucleic acids, and cells. To maintain accuracy and reproducible results it's vital to calibrate centrifuges regularly. Serving biopharmaceutical clients throughout California, GL Technologies is an ISO 17025 company that provides equipment calibration and certification services to maintain accurate results in our clients' laboratories and manufacturing processes.

To speak with the experts about your centrifuge calibration needs, please fill out our online form or give us a call!


What is a Centrifuge?

A centrifuge is a mechanical device that is designed to spin samples at high speeds, generating a centrifugal force that causes particles within the sample to separate based on their densities. The force drives denser materials towards the outer edges, forming distinct layers, while less dense components remain closer to the center. Centrifuges operate on the principle of sedimentation, exploiting the varying settling rates of different substances under gravitational force.

The Importance of Centrifuge Calibration

Centrifuges are complex instruments that rely on exact rotational speeds to separate samples properly. Over time, factors such as general wear and tear, temperature fluctuations, and rotor imbalances can lead to deviations in the equipment's performance. The deviation can impact the separation efficiency which can result in inconsistent results and compromised product quality.

Accurate Results

A properly calibrated centrifuge verifies measurements of variables such as speed, force, and time, which are key for the separation and analyzing substances in smples. Calibration guarantees that the centrifuge operates at the specified parameters, minimizing erros and inconsistencies that can compromise the validity of experimental data. Calibration verifies the performance of the centrifuge in biopharmaceutical research.


With biopharmaceutical research and manufacturing, consistency is the name of the game. A calibrated centrifuge guarantees that samples undergo uniform and predictable centrifugal forces that give researchers the ability to obtain reliable and reproducible results. Whether it's separating blood components or purifying proteins, the calibration process makes sure the centrifuge is operating at its designated speed and acceleration which minimizes experimental errors.

Regulatory Compliance

The biopharmaceutical industry has strict regulatory compliance standards they have to maintain such as Good Manufacturing Practices (cGMP). By adhering to calibration protocols, organization's can demonstrate their commitment to quality control, data integrity, and compliance with regulatory requirements showing the commitment to the safety and quality of their products.

The Centrifuge Calibration Process

The calibration process typically involves the following steps:

Establishing Calibration Standards

The goal of this process is to establish standards that validates the performance of the centrifuge, allowing for exact measurements and reproducible outcomes. During calibration, a series of known samples with defined properties are carefully placed in the centrifuge and the behavior is observed and recorded. By comparing the observed results with the expected values, any issues can be identified and adjustments made to the centrifuge's settings.


Verification is a center point of this process, confirming the proper functioning and calibration of the centrifuge. The operator checks the rotor for any signs of damage or wear, then the calibration standards are carefully prepared following established protocols and placed in the centrifuge. The centrifuge is turned on and allowed to stabilize at the desired speed. A calibration run is performed and the readings are compared against the expected values. Any discrepancies are documented and adjustments are made to align the centrifuge with the required specs.


The speed control system is calibrated using a techometer and reference standards. The technician then carefully adjust the speed settings, making sure they correspond to the desired rotational speeds. The timer system is then calibrated, aligning it with a reference closet to guarantee time measurements. The temperature control sytsem is verified using a thermometer and adjusted to maintain the needed temperature range. Finally, the imbalance detection system is calibrated by placing reference weights at specific location and adjusting the sensitivity settings. Through the calibration process, the centrifuge is ready to deliver consistent and accurate results.


It's important to maintain detailed records of all calibration procedures performed that needs to include the dates, times, measurements, and any adjustments that were made. It also need to be documented any deviations observed. Documentation provides quality control and meets compliant standards for inspections or audits.

Why GL-Tec?

The GL Technologies team has the experience and equipment to calibrate all types of display equipment accurately. We understand the importance of accurate measurements in your specific industry, and we're committed to providing you with reliable, traceable calibration services.

Our calibration services are ISO 17025 accredited, and we follow strict quality control procedures. Your equipment is calibrated to the highest standards. We also provide fast turnaround times, so you can get back to work with minimal downtime.

About GL Technologies

As a full-service company specializing in equipment calibration, repair, and certification services for biopharmaceutical, pharmaceutical, and medical device industries. Our team has extensive experience working with sPRT calibrations along with CMMS softwareHPLC OQ validation, and fume hood certifications. Companies of all sizes rely on our team to implement, maintain, and keep their research and manufacturing processes compliant with regulatory standards. Other specialties include building maintenance systems, and mass spectrometry calibrations. For any centrigue calibrations or repairs, we service all of San Diego, Orange County, Los Angeles, and San Francisco!

To speak with the experts about your centrifuge calibration needs, please fill out our online form or give us a call!



To request a quote from GL-Tec, please fill out our online form and we will get back to you promptly.


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