sPRT Calibration

In biopharmaceutical manufacturing, precision and accuracy are critical. The reliable measurement of temperature is important to maintain the quality and safety of biopharmaceutical products. To provide accurate temperature measurements, the calibration of temperature sensors like the standard platinum resistance thermometers (sPRTs), is vital. GL Technologies works with biopharmaceutical organizations throughout California for their equipment calibration needs including sPRT's. We are experts in biopharma manufacturingand our clients rely on us to keep them compliant with regulatory agencies and their products safe and effective.

To speak with the experts about your sPRT calibration needs, please fill out our online form or give us a call!

858-202-1408

Significance of sPRT in BioPharma

Understanding sPRT Calibration

sPRTs are widely used in biopharma manufacturing because of their stability, linearity, and accuracy. These sensors operate on the principle of the temperature-dependent resistance of a platinum wire. sPRTs require regular calibration to maintain their accuracy against a reference standard.

Calibration involves comparing the resistance values of the sPRT at various known temperatures against the reference standard. By establishing a calibration curve, the relationship between temperature and resistance is determined providing exact temperature measurements during biopharma processes.

Maintaining Product Quality and Safety

For biopharmaceutical manufacturing, maintaining strict temperature control is important for product quality and safety. Most bioprocesses including fermentation, cell culture, and protein purifications are temperature-sensitive. A slight deviation from the required temperature range can impact product yield and purity.

By calibrating sPRTs, manufacturers can accurately monitor and control temperature conditions. This improves process conditions, minimizes the risk of product variability, and improves batch-to-batch consistency. Accurate temperature measurements also contribute to meeting regulatory standards and reduce potential non-compliance issues.

Regulatory Compliance

Biopharmaceutical manufacturing is subject to strict regulations and guidelines set forth by the FDA to emphasize the importance of accurate temperature control and monitoring throughout the manufacturing process.

Calibration of sPRTs is a fundamental aspect of maintaining compliance. Regulatory agencies require documented evidence of sensor calibration as part of their inspections. By having a calibration program in place, organization's can demonstrate their commitment to quality and patient safety.

Cost Reduction and Efficiency

While the goal of sPRT calibration is to verify accuracy, it also has cost-saving implications. Accurate temperature measurements contribute to efficient energy usage and minimizes resource waste. By maintaining exact temperature control, biopharma manufacturer's can improve overall process efficiency and reduce cycle times.

Regular calibration also helps to identify any drft or deviations in sensor performance. Early detection of potential issues allow or quick sensor maintenance or replacement, preventing potential process disruptions and costly downtime.

Frequently Asked Questions

How accurate is the SPRT sensor?

The sPRT (Standard Platinum Resistance Thermometer) sensor is known for its accuracy in temperature measurements. Based on the fundamental properties of platinum, the sPRT sensor provides high precision and stability. When properly calibrated and used in controlled conditions, the sPRT sensor can achieve accuracies of a fraction of a degree Celsius or better. Its accuracy is traceable to international standards providing reliable and consistent results. It’s widely used in scientific research and metrology applications where exact temperature measurements are required.

What is SPRT sensor?

The Standard Platinum Thermometer (sPRT sensor) is a highly accurate temperature sensor that relies on the resistance change of platinum wire with temperature variations It is recognized as a primary standard for temperature measurement because of its stability, linearity, and repeatability over a broad temperature range. The sensor is constructed by winding a platinum wire around a ceramic or glass core within a protective sheath. Its resistance is measured using a 4-wire configuration which minimizes lead wire effects and improves accuracy. The precise calibration and traceability of sPRT sensors makes them an indispensable tool in biopharma research industries, metrology applications, and industrial processes.

How do you calibrate a temperature resistance detector?

Calibrating a temperature resistance detector includes a series of steps to verify accurate temperature measurements. To start, the detector is connected to a reference temperature source like a calibrated thermometer. The reference source is set to a known temperature and the resistance detector’s output is observed. Any deviations from the expected value are documented. Next, adjustments are made to the detector’s calibration settings to bring its output in line with reference temperatures. This process may involve changing software settings or modifying calibration resistors. The calibration is then repeated at multiple temperature points spanning the intended operating range to establish a calibration curve. To finish, the detector’s performance is verified periodically using traceable reference sources.

What are the sources of error in sPRT calibration?

The calibration of sPRTs involves certain sources of error that can affect the accuracy of the calibration process. The sources include uncertainties in the reference temperature measurements, drift, or instability in the resistance standard used for calibration and thermal gradients and hysteresis effects within the calibration bath. Insufficient thermal contact between the sPRT and the calibration medium along with uncertainties associated with the measurement equipment used for resistance and temperature readings are also some sources of errors. The various sources of errors highlight the importance of careful experimental design, precise measurement techniques, and regular calibration checks.

What are the common challenges in sPRT calibration?

A key challenge is the stability of the sensor’s resonant frequency, which can be affected by factors including mechanical stress, temperature variations, and age. Maintaining the sensor’s resonance stability requires careful handling and periodic recalibration. Another challenge lies in achieving accurate and precise temperature measurements, as the calibration process involves establishing a reliable relationship between the sensor’s output signal and the corresponding temperature. Maintaining traceability and adherence to recognized calibration standards is important for reliable and consistent temperature measurements.

How does sPRT calibration differ from other calibration methods?

There are several aspects that sPRT calibration differs from other calibration methods, to start, sPRT calibration relies on the use of a platinum resistance thermometer, which is a primary standard due to its high accuracy and stability. Other calibration methos may use different types of temperature sensors or secondary standards. Also, sPRT calibration involves determining the resistance of the platinum thermometer at several reference temperatures and comparing it to the specified “resistance-temperature” relationship. In contrast, other calibration methods employ different techniques such as thermocouple comparison or fixed point calibration, which have their own advantages and limitations.

sPRT Popular Articles

How sPRTs Improve Biopharmaceutical Manufacturing

The biopharmaceutical industry has witnessed remarkable advancements in recent years, drastically changing the way we treat diseases and improve patient care. One significant breakthrough that has changed the manufacturing process is the use of Single-Use Pressure Sensors (sPRTs). These sensors have proven to play a vital role increasing efficiency, improving quality, and reducing costs in biopharmaceutical production.

Temperature Accuracy in Biopharma: The Crucial Role of sPRTs

In the world of biopharmaceuticals where precision and reliability are of the utmost importance, temperature monitoring stands as a linchpin for verifying the potency and safety of products. Within this domain, the significance of Standard Platinum Resistance Thermometers (sPRTs) cannot be overstated. These highly precise temperature sensors play a role in maintaining the integrity of sensitive biopharmaceutical processes, protecting both quality and compliance standards.

To speak with the experts about your sPRT calibration needs, please fill out our online form or give us a call!

858-202-1408

About GL Technologies

As a full-service company specializing in equipment calibration, repair, and certification services for biopharmaceutical, pharmaceutical, and medical device industries. Our team has extensive experience working with sPRT calibrations along with CMMS software, HPLC OQ validation, and fume hood certifications. Companies of all sizes rely on our team to implement, maintain, and keep their research and manufacturing processes compliant with regulatory standards. Other specialties include building maintenance systems, and mass spectrometry calibrations. GL Technologies provides sPRT calibration services to clients throughout California including San Diego, Los Angeles, and San Francisco just to name a few locations that our clients facilities are in.

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