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San Diego sPRT Calibration

In the bipoharmaceutical and pharmaceutical industries, maintaining precise temperature control is important for maintaining the quality and efficacy of drugs, vaccines, and other temperature sensitive products. Temperature measurement devices are used to monitor and control temperature conditions throughout the manufacturing and storage processes. A popular device that is used is the sPRT (standard platinum resistance thermometer), this instrument is highly a highly accurate instrument used for temperature calibration. The team at GL Technologies has extensive experience working with bioparmaceutical and pharmaceutical clients throughout the San Diego region. We specialize in equipment calibration and certification services to keep our clients research and manufacturing processes compliant with industy regulations and their equipment accurate.

To speak with the experts about your sPRT calibration needs, please fill out our online form or give us a call!


Accurate Temperature Sensors

Standard platinum resistance thermometers (sPRTs) are recognized as the most accurate temperature sensors in the industry. These specialized instruments rely on resistance changes of platinum wire to determine temperature. To maintain accuracy, sPRTs require regular calibration against a reference standard. The GL Tec process for calibration involves comparing the readings of the sPRT with those of a known and traceable temperature source. This process works to identify any deviations or errors in the measurements produced by the sPRT.

Importance of sPRT Calibration in Biopharma

Compliance with Regulatory Standards

Verifying the integrity of temperature sensitive processes and compliance with strict regulatory requirements, regular calibration of sPRTs is of utmost improtance. Calibration guarantees that these thermometers maintain their accuracy within specified limits and provide reliable and traceable data for drug manufacturing processes including storage and transportation. Compliance with industry standards such as cGMP (Good Manufacturing Practices) is important to meet regulatory expectations.

Product Quality Assurance

sPRT calibration is important to maintain and validate temperature-sensitive processes and equipment used in pharmaceutical manufacturing. Calibration of sPRTs is a step that guarantes the accuracy and precision of temperature readings, thus maintaining compliance with strict regulatory requirements. With teh assurance of exact temperature measurements, biopharma organizations can maintain the integrity of their products, improve internal processes and protocols, and deliver safe medications and therapies to patients and partner companies.

Process Optimization

Over the past decade, advancements in calibration techniques and automation have significantly improved the efficiency and accuracy of the process, allowing biopharmaceutical and pharmaceutical companies to improve their manufacturing processes. Accurate temperatures control not only verifies the safety and efficacy of biopharma products btu also improves the overall process efficiency, resulting in higher yields and reduced production costs. As the biopharma industy continues to evolve, calibration pratices for sPRTs remains a cornerstone of process optimization, driving innovation and maintaining the industry's commitment to producing high-quality products.

To speak with the experts about your sPRT calibration needs, please fill out our online form or give us a call!


Benefits of sPRT Calibration

Improved Measurement Accuracy

One of the significant advantages of sPRT calibration is the enhancement of measurement accuracy. Through qualified calibration processes, sPRTs can achieve precision in temperature readings so that measurements are reliable and traceable to both domestic and international standards. Improved measurement accuracy results in reduced uncertainties, leading to beter control over processes in biopharma indsturies such as research, manufacturing, and quality control. The reliable performance of sPRTs after calibration provides more confident decision-making and maintains compliance with regulatory requirements. The calibration process can also identify any deviations or inaccuracies in the instrument's performance which allows for timely corrective actions.

Traceability and Documentation

With sPRT calibration, traceability and documentation stand out as important advantages. Traceability makes sure that the measurement results of an sPRT can be directly linked to domestic and international standards, guaranteeing accuracy and reliability. By implementing a well-documented calibration process, the sPRTs performance and deviations can be recorded and analyzed over time, allowing for easy verification of its accuracy and consistency. This documentation not only works to meet regulatory requirements, but also gives confidence to users and promotes trust in the instrument's measurements. It also facilitate easy comparison and sharing of data across different labs, fostering collaboration within the scientific and manufacturing teams.

Instrument Lifespan

sPRT calibration goes beyond exact temperature measurements, it also encompasses an extended instrument lifespan, making it a crucial practice for temperature-dependent industries. Regular calibration maintains the sPRT accuracy and reliability over time, minimizing measurement errors that can lead to costly operational setbacks or compromised product quality. By having a well-defined calibration schedule, potential deviations in temperature readings can be detected and corrected, preventing the need for unneeded instrument replacement.

Best Practices for sPRT Calibration

Frequency of Calibration

There are several factors to consider for the frequency of calibration. First, it's important to adhere to the manufacturer's recommendations, they provide guidelines specific to the sPRT model. Additionally, the frequency should be determined based on the criticality of the measurements and the instrument's usage. Instruments that are used in important processes or an industry with strict regulations, like the biopharma industry, require more frequent calibrations, usually on an annual basis. sPRTs used in less demanding environments can potentially be calibrated every 2 years. Regular performance checks and comparisons against a traceable standard should be conducted between formal calibrations.

Calibration Procedures

It's important to perform regulat checks on sPRT's reference resistors and inspect them for signs of drift. Using a high-accuracy temperature bath with a stable and defined temperature point is recommended to establish a reliable calibration reference. The calibration procedures needs to involve multiple temperature points spanning the instrument's operating range to cover various scenarios. During calibration, GL Technologies will keep detailed record of the calibration process including environmental conditions which allows for traceability and facilitates troubleshooting.


Before starting the calibration procedure, it's vital to record the sPRT's unique identification number and previous calibration details. During calibration, our team will adhere to regulatory standards and document each step, including the reference thermometer used, environmental conditions, and any adjustments that were made. For traceability, a comprehensive calibration history log for each sPRT should be maintained noting dates, technicians involved, and measurement uncertainties. Always cross-reference documetnation with measurement results and update records accordingly.

sPRT Popular Articles

How sPRTs Improve Biopharmaceutical Manufacturing

The biopharmaceutical industry has witnessed remarkable advancements in recent years, drastically changing the way we treat diseases and improve patient care. One significant breakthrough that has changed the manufacturing process is the use of Single-Use Pressure Sensors (sPRTs). These sensors have proven to play a vital role increasing efficiency, improving quality, and reducing costs in biopharmaceutical production.

Temperature Accuracy in Biopharma: The Crucial Role of sPRTs

In the world of biopharmaceuticals where precision and reliability are of the utmost importance, temperature monitoring stands as a linchpin for verifying the potency and safety of products. Within this domain, the significance of Standard Platinum Resistance Thermometers (sPRTs) cannot be overstated. These highly precise temperature sensors play a role in maintaining the integrity of sensitive biopharmaceutical processes, protecting both quality and compliance standards.

To speak with the experts about your sPRT calibration needs, please fill out our online form or give us a call!


GL Technologies Capabilities

As a full-service company specializing in equipment calibration, repair, and certification services for biopharmaceutical, pharmaceutical, and medical device industries. Our team has extensive experience working with sPRT calibrations along with CMMS software, HPLC OQ validation, and fume hood certifications. Companies of all sizes rely on our team to implement, maintain, and keep their research and manufacturing processes compliant with regulatory standards. Other specialties include building maintenance systems, and mass spectrometry calibrations.


To request a quote from GL-Tec, please fill out our online form and we will get back to you promptly.


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