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HPLC Maintenance Lab Equipment

The team at GL Technologies provides a wide variety of instrument and equipment repair and services for both organizations large and small. We are also experts at providing support for HPLC instruments that have been discontinued or longer "cared-for" by the original manufacturer. These types of legacy instruments can be supportable for years to come by GL-Tec's ability to find and work on older instruments not supported by OEM.

To speak with the experts about your HPLC needs, please fill out our online form or give us a call!


The Role of HPLC in Laboratories

HPLC is a versatile and precise analytical tool, primarily used for separating, identifying, and quantifying compounds in complex mixtures. It plays a crucial role in various applications, including pharmaceutical research, quality control, environmental monitoring, food analysis, and more. Maintaining the reliability and accuracy of your HPLC system is essential to ensure the validity of your results and the integrity of your research.

Common HPLC Issues

Despite their robust design and quality, HPLC instruments can experience technical problems over time due to wear and tear, misalignment, or component failures. Some common issues laboratories may face include:

Pressure Fluctuations

Pressure fluctuations can come from a variety of sources and can significantly impact the reliability and performance of an HPLC system. The fluctuations can be caused by issues such as air bubbles in the solvent lines, clogged blocked columns, leaks in the system, or problems with the pump. Monitoring and troubleshooting pressure fluctuations is important to maintain the accuracy and precision of HPLC analysis as they can lead to baseline drift, reduced peak resolution, and suboptimal separations.


Leakage can occur at various points in the HPLC system in areas including fittings, connections, and seals, and are a result of wear and tear, improper assembly, or components degrading over time. Leaks not only lead to a loss of sample and mobile phase but also contaminate the system, affecting the integrity of subsequent analysis.

Detector Problems

Detector issues can create a range of challenges including baseline drift, noise, or even complete signal loss. Baseline drift can result from mobile phase impurities, column contamination, or fluctuations in the detector’s lamp intensity, leading to distorted peak shapes and quantification. Noise in the detector signal can stem from electrical interference or a dirty flow cell, causing reduced sensitivity and higher limits of detection. Signal loss can occur due to detector malfunctions such as a faulty detector cell, requiring quick maintenance to restore it back to it’s required performance.

Pump Issues

Pump issues can start in several ways, including flow rate fluctuations, pressure irregularities, or leaks in the pump system. These problems can result from worn-out seals, blocks in the pump head, or check valves not working correctly. To address pump issues, regular maintenance, such as replacing worn out components and proper solvent filtration is vital.

Column Problems

Columb problems can start in a few ways including poor peak shape, reduced sensitivity, or inconsistent retention times. Common issues include column degradation due to sample carryover, particulate contamination, or column overloading. Proper maintenance and regular cleaning are important to minimize these column-related challenges.

The Importance of Professional HPLC Repair Services

Precision and Expertise

Precision and expertise are the cornerstone of HPLC maintenance and repair, maintaining accuracy and reliability of HPLC system is vital for pharmaceutical and biopharmaceutical research. The GL Technologies technicians have specialized knowledge and can diagnose and fix intricate issues, working to prevent downtime, data inaccuracies, and costly instrument replacements. Our proficiency in maintaining HPLC equipment protects the integrity of analytical results while contributing to the longevity of HPLC instruments.

Quick Turnaround

When HPLC systems experience malfunctions or downtime, it can disrupt workflows, delay experiments, and compromise the data. This is why GL Technologies provides fast and precise restoration of HPLC equipment for our clients. We are staffed by expert technicians proficient in diagnosing and resolving issues, making sure the uninterrupted operations of these instruments. A fast turnaround minimizes costly disruptions and maximizes lab efficiency.

Preventive Maintenance

Regular preventive maintenance carried out by GL Technologies can identify and fix any issues before they escalate, which reduces costly downtime and the risk of data inaccuracies. This is a proactive approach company’s take that not only extends the lifespan of the equipment but also improves the overall efficiency of analytical processes, allowing researchers to maintain the highest standards of data quality and research integrity.

Compliance and Validation

HPLC instruments are susceptible to wear and tear, calibration issues, and malfunctions, which can lead to non-compliance with industry standards and regulatory requirements. Timely and expert HPLC repair services are important to maintain the integrity of analytical data, protect product quality, and support adherence to strict regulations, which uphold public health and safety standards.

What is HPLC?

HPLC is the acronym for "high-performance liquid chromatography". It is a widely used and popular technique in laboratories for analytical chemistry used to separate, identify and quantify each component in a mixture.

As related technologies become more sophisticated, the system commonly referred to as a "High Performance Liquid Chromatography" simply became referred to as "LC". In today's age, the Ultra High Performance Liquid Chromatography is referred to as UHPLC and is capable of high-speed analysis, is becoming more popular amongst organizations.

GL Technologies Capabilities

As a full-service company specializing in equipment calibration, repair, and certification services for biopharmaceutical, pharmaceutical, and medical device industries. Our team has extensive experience working with sPRT calibrations along with CMMS software, HPLC OQ validation, and fume hood certifications. Companies of all sizes rely on our team to implement, maintain, and keep their research and manufacturing processes compliant with regulatory standards. Other specialties include building maintenance systems, and mass spectrometry calibrations.

To speak with the experts about your HPLC needs, please fill out our online form or give us a call!



To request a quote from GL-Tec, please fill out our online form and we will get back to you promptly.


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