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San Francisco Thermo Scientific HPLC Calibration

The biopharmaceutical industry continues to be one of the fastest-growing sectors in the San Francisco, with an increasing demand for drugs and therapies to treat a wide range of diseases. As such, the need for accurate and reliable testing methods is essential to maintain the safety and effectiveness of these drugs. High-performance liquid chromatography (HPLC) is a commonly used analytical technique in the biopharma industry, and calibration of HPLC systems is important to achieving accurate and precise results. In San Francisco, If your laboratory is utilizing Thermo Scientific equipment and you need a reliable and trusted equipment calibration and certification provider, GL-Tec offers expert calibration services so that biopharmaceutical companies can rely on their HPLC systems to produce consistent and accurate results.

To speak with the experts about your Thermo Scientific HPLC needs, please fill out our online form or give us a call!


Experts in HPLC Calibration Services

GL Technologies is a leading provider of calibration services in San Francisco. With a team of experienced professionals, We offer comprehensive Thermo Scientific HPLC calibration services to ensure that biopharmaceutical companies can rely on their HPLC systems to produce accurate and consistent results.

For biopharmaceutical companies and medical companies using state-of-the-art Thermo Scientific equipment, GL-Tec understands the techniques to calibrate HPLC systems, ensuring that all parameters are adjusted to the correct values. We also offer validation services to ensure that the HPLC system is performing within the required specifications.

Key Components of HPLC Calibration

There are several critical components to consider during the HPLC calibration process:

Calibration Standards

Calibration standards, typically composed of pure chemical compounds with known concentrations, establish a baseline for analyzing and calibrating the chromatographic system. They aid in evaluating parameters including retention times, peak resolution, and detector response. By comparing the chromatographic behavior of these standards against the instrument's output, technicians can fine-tune settings, verify the system's performance, and ascertain the precision and linearity of measurements. Accurate calibration standards are vital in validating the HPLC system's functionality, guaranteeing the credibility of analytical results

Calibration Frequency

The calibration frequency is determined by several factors, including instrument stability, usage frequency, regulatory requirements, and the criticality of the analysis. Regular calibration intervals guarantee precision and accuracy in analytical results by fixing any deviations or drifts in the system's performance. Striking the right balance in calibration frequency makes sure that the HPLC system maintains its accuracy, sensitivity, and reproducibility, upholding the quality standards in pharmaceutical, clinical, and research settings.

System Suitability Testing

These components primarily include parameters like resolution, tailing factor, retention time, and theoretical plates. Resolution measures the ability of the chromatographic system to separate 2 adjacent peaks, indicating its efficiency. The tailing factor evaluates the symmetry of peaks so that they are appropriately shaped and not distorted, which could affect accuracy. Retention time signifies the time taken for a compound to emerge from the column, aiding in compound identification and quantification. Theoretical plates assess the column's efficiency in separating components, reflecting the system's overall performance. Successful calibration through System Suitability Testing guarantees the accuracy, reliability, and reproducibility of HPLC analysis, maintaining consistent and precise results in pharmaceutical and research applications.


Calibration records document detailed information about calibration standards, their traceability, preparation, and usage during calibration. System suitability test results demonstrate the instrument's capability to produce consistent and reliable chromatographic separations. Any deviations experienced during calibration procedures, along with corrective actions taken, are recorded to maintain compliance with regulatory standards and data integrity. These components collectively establish a comprehensive documentation framework important for HPLC calibration, facilitating the generation of accurate and reliable analytical data in pharmaceutical and analytical laboratories.

Thermo Scientific HPLC Education

Fine-tuning HPLC Calibration for Biopharma Excellence

In the evolving world of biopharmaceuticals, High-Performance Liquid Chromatography (HPLC) stands as a pillar analytical technique. It allows for the separation, identification, and quantification of compounds that are vital to the development, production, and quality control of biopharmaceuticals. HPLC calibration plays a role in maintaining the accuracy, reliability, and excellence of analytical results in this industry.

The Intersection of HPLC and Biopharmaceutical Innovation

In the wordl of biopharmaceuticals, the advancement of analytical techniques plays a pivotal role in making sure the safety, efficacy, and quality of therapeutic drugs. High-Performance Liquid Chromatography (HPLC) stands at the forefront of these technological advancements, driving innovation and precision in the development and manufacturing processes of biopharmaceuticals.

Biopharma HPLC for Small and Large Molecule Analysis

High-Performance Liquid Chromatography (HPLC) has long been a cornerstone technique in the field of biopharmaceutical analysis. It plays a crucial role in the separation, quantification, and characterization of various compounds, including both small and large molecules. In the world of biopharmaceuticals, the significance of HPLC cannot be overstated. We'll explore the role of HPLC in biopharma, focusing on its application in the analysis of both small and large molecules.

About GL Technologies

As a full-service company specializing in equipment calibration, repair, and certification services for biopharmaceutical, pharmaceutical, and medical device industries. Our team has extensive experience working with sPRT calibrations along with CMMS softwareHPLC OQ validation, and fume hood certifications. Companies of all sizes rely on our team to implement, maintain, and keep their research and manufacturing processes compliant with regulatory standards. Other specialties include building maintenance systems, and mass spectrometry calibrations.

To speak with the experts about your Thermo Scientific HPLC needs, please fill out our online form or give us a call!



To request a quote from GL-Tec, please fill out our online form and we will get back to you promptly.


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