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La Jolla HPLC Repair and Maintenance

GL Technologies is one of San Diego's premier HPLC repair and maintenance providers for biopharmaceutical and pharmaceutical organizations throughout La Jolla and the entire Southern California region. Like any sophisticated instrument, HPLC systems require regular maintenance and occasional repairs to maintain peak performance and deliver accurate results consistently.  Our technicians are trained in everything HPLC specializing in all HPLC manufacturer brands including Agilent, Shimadzu, Thermo Scientific, Dionex, and more.  If you are in need of a qualified and trusted company for your HPLC needs, please reach out to us!

To speak with the experts about your HPLC needs, please fill out our online form or give us a call!


HPLC Systems in Pharmaceutical Settings

HPLC systems are valuable tools in pharmaceutical laboratories, facilitating the analysis of complex mixtures with high sensitivity and efficiency. They are used in various stages of drug development and production, including research, quality control, and regulatory compliance.

These systems have intricate components including pumps, injectors, columns, detectors, and software, all working together o execute exact chromatographic analyses. Any malfunction or degradation in performance can jeopardize the integrity of results, potentially leading to costly delays, compromised product quality, or regulatory non-compliance.

Why Routine Maintenance is Important

Regular maintenance is the key to preserving the functionality and longevity of HPLC systems. A proactive approach to maintenance not only minimizes the risk of unexpected breakdowns but also maintains consistent performance and accurate results over time. Key maintenance tasks include:

Instrument Calibration

Regular calibration of HPLC components provides accurate measurement and detection of analytes. Calibration protocols should adhere to industry standards and be performed at specified intervals.

Column Care

Proper care and maintenance of chromatographic columns are essential for separation efficiency and column longevity. This includes regular flushing, conditioning, and periodic replacement as per usage guidelines.

Solute Solvent Compatibility

Compatibility between solvents and sample solutes is important to prevent damage to system components and keep accurate results. Careful selection and handling of solvents are imperative to avoid contamination or degradation of system performance.

Routine Inspections

Regular visual inspections of system components help identify potential issues such as leaks, blockages, or wear and tear. Addressing these issues quickly can prevent more significant problems down the line.

Troubleshooting and Repair

Despite  maintenance, HPLC systems may encounter issues that require troubleshooting and repair. Common problems include pump failures, injector malfunctions, detector drift, and software glitches. Diagnosis and resolution of these issues are important to minimize downtime and maintain productivity.

Diagnostic Tools: Modern HPLC systems are equipped with diagnostic tools and software algorithms that aid in identifying performance deviations and possible failures. Regular system checks and diagnostics can detect issues early, allowing for timely intervention.

Qualified Service Providers: In cases where repairs are necessary, it's important to bring in the team at GL-Tec's qualified technicians with expertise in HPLC systems. As an authorized providre, we can diagnose problems accurately, source genuine replacement parts, and perform repairs in accordance with manufacturer guidelines.

Preventive Measures: In addition to reactive repairs, implementing preventive measures can minimize the risk of future breakdowns. This includes adhering to recommended maintenance schedules, implementing quality control procedures, and investing in staff training to improve instrument operation and troubleshooting skills.

Popular HPLC Articles

Troubleshooting HPLC Systems in Pharmaceutical Settings

High-Performance Liquid Chromatography (HPLC) is a common technique in pharmaceutical analysis, providing precise separation and quantification of compounds. However, like any analytical method, HPLC systems can encounter issues that impede their functionality. In a pharmaceutical setting where accuracy and reliability are vital, quick and effective troubleshooting is important to maintain productivity and maintain the quality of results.

HPLC: A Cornerstone in Drug Development and Testing

In the pharmaceutical industry, the safety and quality of drugs is vital This assurance is achieved through rigorous testing and analysis at various stages of drug development and production. One powerful tool in this process is High-Performance Liquid Chromatography (HPLC). HPLC stands as the key in drug development and testing, playing an important role in the pharmaceutical industry's quest for excellence and innovation.

HPLC Calibration and Repair for Pharmaceutical Applications

High-Performance Liquid Chromatography (HPLC) is an indispensable tool in pharmaceutical analysis, playing an important role in verifying the quality, safety, and potency of drugs. For HPLC systems to deliver accurate and reliable results, proper calibration and maintenance are essential. GL Technologies discusses the critical steps involved in HPLC calibration and repair specifically tailored for pharmaceutical applications.

Why GL-Tec?

As a full-service company specializing in equipment calibration, repair, and certification services for biopharmaceutical, pharmaceutical, and medical device industries. Our team has extensive experience working with sPRT calibrations along with CMMS softwareHPLC OQ validation, and fume hood certifications. Companies of all sizes rely on our team to implement, maintain, and keep their research and manufacturing processes compliant with regulatory standards. Other specialties include building maintenance systems, and mass spectrometry calibrations

To speak with the experts about your HPLC needs, please fill out our online form or give us a call!



To request a quote from GL-Tec, please fill out our online form and we will get back to you promptly.


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