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San Francisco HPLC Repair and HPLC Maintenance

High pressure liquid chromatography (HPLC) is commonly used in the biotech and pharmaceutical laboratories throughout the San Francisco region. GL Technologies has become one of California's trusted specialists when HPLC maintenance or HPLC repairs are needed. With a team of experts that have industry experience with HPLC, the righ questions will be asked to get lab managers into the right HPLC maintenance program. Using a stainless steel column along with a liquid phase to separate components out of a mixture. The HPLC process has grown tremendously over the past few years to iincrease lab productivity. If you are in need of a quality team of consultants for HPLC repairs or help implementing an HPLC maintenance program, we are ready to help!

To request more information or a quote, please fill out our online Request Information form or call!


HPLC Maintenance and Repair Contractors

When you work with the team at GL-Tec, you will get the attention your organization needs and not pushed to the back of the line. There are a few components that are HPLC maintenance contractors cover including:

Parts and Labor

When your organization has deemed your HPLC instrument/s as a vital piece to your laboratories operations, GL-Tec suggest a contract that includes parts and labor. We always emphasize how important preventative maintenance is for HPLC instruments, but many laboratory and facility managers tend to plan for their entire annual repair and maintenance budgets. The organizations that work with GL-Tec rarely have any surprise costs throughout the year (including downtime).

Preventative Maintenance

The key to longevity for your HPLC instrument is preventative maintenance. With regularly schedule maintenance, deeper issues can be found that have the potential to cause productivity issues and downtime. We understand that a preventative maintenance contract can take your instrument out of use for a day or 2, which is why we provide flexibility for our clients. If a prevenative maintenance plan needs to be rescheduled, no problem there. We will schedule everything when its convenient for your facility. San Francisco High Performance Liquid Chromatography Services

HPLC Qualification Services

All of our preventative maintenance plans are customized to your needs. GL-Tec provides HPLC qualificaiton or performance verification services with compliant documentation to meet the regulatory requirements. The GL-Tec qualification specialists are ready to execute IQ/OQ/PQ Custom protocols that are all tailored to your specifications.

As many facilities, organizations and laboratories currently do, you can rely on the team at GL-Tec to provide cost-effective services for HPLC, maintenance, calibration and performance verifications.

Key Maintenance Protocols

Regular System Checks

Conduct routine inspections of the HPLC system components. Check for leaks, unusual noises, or irregular pressure readings. Inspect tubing, fittings, and seals for wear or damage. Perform a visual examination of the columns and detectors for any signs of degradation.

Cleaning Procedures

Implement a strict cleaning regimen for the HPLC components. Thoroughly clean and flush the system to prevent residue buildup that might affect results. Use appropriate solvents and follow manufacturer-recommended cleaning protocols for each component.

Calibration and Performance Verification

Regularly calibrate the HPLC system to maintain accuracy in measurements. Verify system performance using standard solutions to validate the accuracy and precision of the instrument. Conduct system suitability tests to confirm proper functioning before sample analysis.

Column Care

Columns are crucial in separation and analysis. Follow manufacturer guidelines for column care, including proper storage conditions, flushing protocols, and replacement timelines. Regularly regenerate, flush, or replace columns based on usage and performance criteria.

Software Updates and Backups

Keep HPLC software up-to-date with the latest versions and patches provided by the manufacturer. Regularly back up method parameters, data, and system settings to prevent loss of crucial information.

Training and Documentation

Train laboratory personnel on proper HPLC maintenance procedures and protocols. Maintain detailed records of all maintenance activities, including cleaning schedules, calibration logs, and system performance assessments.

Benefits of Proactive Maintenance

Implementing proactive HPLC maintenance protocols in biopharma laboratories offers numerous advantages:

Improved Data Accuracy

Regular maintenance routines, including scheduled checks, component replacements, and system calibrations, contribute significantly to improved data precision and reliability. By pre-emptively identifying and fixing issues, such as pump malfunctions, column degradation, or detector inconsistencies, proactive maintenance minimizes the risk of erroneous readings or inconsistent chromatographic results.

Increased Instrument Longevity

Regular maintenance routines including cleaning, part replacement at recommended intervals, and preventative checks on components like pumps, detectors, and columns prevent premature wear and tear. By addressing minor issues quickly, proactive maintenance minimizes the risk of major breakdowns or malfunctions, prolonging the operational lifespan of the HPLC instrument.

Reduced Downtime

By minimizing potential issues like baseline drift, peak broadening, or irregular retention times, proactive maintenance protects data integrity, allowing for precise and consistent chromatographic outcomes critical for analytical workflows, research, and quality control processes.

Compliance with Regulations

By adhering to scheduled maintenance routines, laboratories not only guarantee peak performance of their equipment but also align themselves with industry regulations and quality standards. Compliance-oriented maintenance practices not only minimize the risk of deviations but also contribute to the reliability and integrity of data produced by HPLC systems.

Trending HPLC Articles

The Intersection of HPLC and Biopharmaceutical Innovation

In the wordl of biopharmaceuticals, the advancement of analytical techniques plays a pivotal role in making sure the safety, efficacy, and quality of therapeutic drugs. High-Performance Liquid Chromatography (HPLC) stands at the forefront of these technological advancements, driving innovation and precision in the development and manufacturing processes of biopharmaceuticals.

Improve HPLC Performance Through Operational Qualification

HPLC (high-performance liquid chromatography) is a widely used analytical technique in the pharmaceutical and biopharmaceutical industries. HPLC provides researchers and analysts with reliable and quantitative data about the composition of complex mixtures. To verify accurate and reproducible results, it’s important to maintain and optimize the performance of the HPLC system. A vital step in this process is OQ (operational qualification). OQ can improve the performance of an HPLC system for organizations in a variety of ways.

About GL Technologies

As a full-service company specializing in equipment calibration, repair, and certification services for biopharmaceutical, pharmaceutical, and medical device industries. Our team has extensive experience working with sPRT calibrations along with CMMS softwareHPLC OQ validation, and fume hood certifications. Companies of all sizes rely on our team to implement, maintain, and keep their research and manufacturing processes compliant with regulatory standards. Other specialties include building maintenance systems, and mass spectrometry calibrations.

To request more information or a quote, please fill out our online Request Information form or call!



To request a quote from GL-Tec, please fill out our online form and we will get back to you promptly.


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