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Sorrento Valley HPLC Calibration and Repair

For Sorrento Valley biopharma and pharmaceutical organizations in Sorrento Valley, HPLC calibration is a technique in in pharma analysis, facilitating the separation, identification, and quantification of compounds with precision. GL Technologies is located right here in the area providing regular calibration of HPLC instruments for our clients.  The GL-Tec team helps our clients to maintain accurate and reliable results while keeping them compliant with industry regulation.  

To speak with the experts about your HPLC calibration needs, please fill out our online form or give us a call!


GL Tec Calibration Testing Procedures

System Suitability Testing (SST)

SST is the initial benchmarking step to evaluate the overall performance of your HPLC system. Parameters include resolution, peak symmetry, retention time, and tailing factor are evaluated using reference standards. Pharmaceutical laboratories must establish acceptance criteria for these parameters based on regulatory guidelines and internal quality standards.

Instrument Calibration

Calibration of individual components within the HPLC system is vital to maintain accuracy. This includes calibration of the pump flow rate, detector wavelength, injection volume, and column temperature. Calibration standards certified by GL Technologies should be used for calibration exercises for traceability and reliability.

Qualification of Reference Standards

Sorrento Valley biopharma and pharmaceutical laboratories rely on reference standards to calibrate and validate HPLC systems. It is important to procure high-quality reference standards from GL Technologies to verify their authenticity through strict testing. Proper storage and handling of reference standards are equally vital to prevent degradation and maintain consistency in results.

Documentation and Traceability

Comprehensive documentation of calibration procedures and results are vital for regulatory compliance and audit readiness. Our calibration records will include details including the date, instrument identification, personnel involved, calibration standards used, and deviations found, if any. Maintaining a strong system for traceability provides accountability and facilitates troubleshooting in case of discrepancies.

Benefits of HPLC Calibration in Pharmaceutical Laboratories

Effective HPLC calibration confirms numerous benefits to pharmaceutical laboratories, including:

Assurance of Data Integrity

By calibrating HPLC instruments, pharmaceutical scientists can confidently rely on the accuracy and precision of their analytical results, vital for quality control and regulatory compliance. Calibration procedures validate the performance of HPLC systems, guaranteeing consistent and reliable output over time. This assurance not only increases the credibility of analytical data but also protects against potential errors or inaccuracies, which upholds the integrity of pharmaceutical research, development, and manufacturing processes.

Compliance with Regulatory Standards

Calibration not only assures the consistency of results but also increases the credibility of data generated, creating trust in the potency and safety of medicinal products. Adherence to regulatory standards set forth by agencies like the FDA or EMA is imperative for maintaining product quality, protecting public health, and meeting industry requirements.

Workflow Efficiency

By calibrating HPLC systems, laboratories minimize the risk of inaccurate results, saving both time and resources by preventing costly retests and potential deviations in product quality. Calibrated instruments streamline workflows, allowing for the integration into pharmaceutical manufacturing processes, which improves productivity and maintains compliance with strict regulatory standards. The implementation of HPLC calibration not only ncreases the reliability of analytical data but also maximizes operational efficiency, reinforcing its role in pharmaceutical laboratories.

Cost Savings

HPLC calibration not only protects product quality but also minimizes the need for rework or product recalls, saving substantial costs associated with production downtime, wasted materials, and regulatory penalties. Calibrated HPLC instruments increase efficiency by streamlining analytical processes, which increases resource utilization. Investing in HPLC calibration creates a culture of quality and reliability, long-term cost savings and overall operational performance in pharmaceutical laboratories.

HPLC Calibration

HPLC calibration is a systematic process aimed at verifying the accuracy and reliability of instrument performance. It involves the adjustment of various parameters to guarantee consistent results over time.

HPLC Resources

HPLC: A Cornerstone in Drug Development and Testing

In the pharmaceutical industry, the safety and quality of drugs is vital This assurance is achieved through rigorous testing and analysis at various stages of drug development and production. One powerful tool in this process is High-Performance Liquid Chromatography (HPLC). HPLC stands as the key in drug development and testing, playing an important role in the pharmaceutical industry's quest for excellence and innovation.

Troubleshooting HPLC Systems in Pharmaceutical Settings

High-Performance Liquid Chromatography (HPLC) is a common technique in pharmaceutical analysis, providing precise separation and quantification of compounds. However, like any analytical method, HPLC systems can encounter issues that impede their functionality. In a pharmaceutical setting where accuracy and reliability are vital, quick and effective troubleshooting is important to maintain productivity and maintain the quality of results.

About GL Technologies

As a full-service company specializing in equipment calibration, repair, and certification services for biopharmaceutical, pharmaceutical, and medical device industries. Our team has extensive experience working with sPRT calibrations along with CMMS softwareHPLC OQ validation, and fume hood certifications. Companies of all sizes rely on our team to implement, maintain, and keep their research and manufacturing processes compliant with regulatory standards. Other specialties include building maintenance systems, and mass spectrometry calibrations.


To request a quote from GL-Tec, please fill out our online form and we will get back to you promptly.


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